Life threatening interaction between tamoxifen and warfarin.
نویسندگان
چکیده
منابع مشابه
Interaction between warfarin and tamoxifen: a case report.
Warfarin is a commonly used anticoagulant with documented reports of drug interactions. Tamoxifen is used in the adjuvant hormonal treatment of women with oestrogen-receptor- positive breast cancer. Warfarin and tamoxifen are known to interact with each other with a resultant increase in the bleeding tendency. These reports are mainly from the white population. We report a case of drug interact...
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A patient is described in whom there was strong circumstantial evidence of an interaction between warfarin and co-trimaxazole. To test the validity of this hypothesis a series of in vitro and in vivo human studies were untaken. The results indicate that interaction may occur in which the sulphamethoxazole moiety of co-trimoxazole displaces warfarin from its binding sites on plasma albumin. Neve...
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For decades, warfarin has been the primary anticoagulant for the primary and secondary prevention of venous and arterial thromboembolic events. There is an extensive amount of literature that has contributed to the understanding of the complex pharmacokinetics and pharmacodynamics of warfarin, its interactions with drugs and other compounds, its antithrombotic effects, and the risks associated ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1989
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.298.6666.93